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It is served by the Bangui MPoko International Airport. The National Assembly, government buildings, banks, foreign enterprises and embassies, hospitals, hotels, main markets and the Ngaragba Central Prison are all located here. Bangui manufactures textiles, food products, beer, shoes and soap. Its Notre Dame Cathedral is the seat of the Roman Catholic Archdiocese of Bangui. The city is also home to the University of Bangui, inaugurated in 1. Bangui has been the scene of intense rebel activity and destruction during decades of political upheaval, including the current rebellion. As a result of political unrest, the city was named in 1. Historyedit. A street scene in Bangui, 1. Archaeological studies in and around Bangui have yielded at least 2. 
Iron Age sites that contain many metallurgical tools and objects, illuminating the pre European history of the city and surrounding area. 3 The archaeological sites were added to the UNESCOWorld Heritage Tentative List on 1. April 2. 00. 6 in the Cultural category. 3 The site closest to Bangui is Pendere Sengue, 8. Independence Avenue, where archaeologists and conservation agencies have carried out studies. It is a paleo metallurgical site where several thousand shards of ceramics, iron tools, pottery, and an iron spatula weighing 9 kilograms 2. Its dating, compared with similar sites in Nigeria and Sudan, could be close to the 9th century BC. 3Bangui was founded by Albert Dolisie and Alfred Uzac on 2. June 1. 88. 9, in what was then the upper reaches of the French Congo, the present day Congo Brazzaville. The original site was 6 miles 9. Ubangi rapids. Its territory was organized first into the territory of the Upper Ubangi Haut Oubangui and then as the separate colony of Ubangi Shari. The initial capitals of these areas were at les Abiras and Fort de Possel further upstream, but the rapids at Bangui blocked them from direct communication along the river and caused the settlement there to grow in importance until, in 1. French administration. Bangui retained its importance as a military and administrative centre when the colony was folded into French Equatorial Africa and under both Vichy and Free French control during World War II. The French operated a radio transmitter in Bangui, which was described in 1. Africa. 5The colony of Ubangi Shari received its autonomy in 1. Central African Republic and this became independent from France in 1. In 1. 97. 0, President Jean Bdel Bokassa inaugurated the University of Bangui. He established the national airline Air Centrafrique the following year and ordered the construction of two new luxury hotels in Bangui. With tensions mounting between Bangui and Paris as a result of Bokassas uncontrollable expenditures, western banks refused to lend him any more money. Relations with the French worsened still further in April 1. Brigette Mirouxs body was discovered in a hotel room in Bangui. It was reported in the French media that she had been Bokassas mistress and that he was responsible for her murder. As a result, Bokassa banned imports of French newspapers and assumed control of the Agence France Presse office in Bangui. By 1. 97. 5, Bangui had a population of 3. In March 1. 98. 1, widespread violence took place in Bangui following elections, after Operation Caban led the French to drop Bokassa who had begun to call himself Emperor Bokassa I, and replaced him with David Dacko. Opponents of the President met in Bangui and were forced to flee the country. After returning voluntarily to Bangui in the autumn of 1. Bokassa went on trial. Initially faced with the death penalty, in February 1. His successor was General Andr Kolingba, army chief of staff of Deckos army, who took over control from the local French military on 1 September 1. Although he attempted to combat corruption and control the national economy, he was unable to achieve his reforms. By the middle of the 1. Under pressure from France and other western countries, Kolingba restored democracy in the country in 1. August 1. 99. 4. During the elections, Ange Flix Patass was elected to the post of president. Since he was from northern CAR, the southern group of Kolingba started a rebellion during 1. In May 1. 99. 6, about 2. Central African Republic mutinied in Bangui, demanding salary increases and the abdication of Ange Flix Patass. 1. In the aftermath, the renegades plundered and killed more than 5. Following this, the French troops stationed in the country suppressed the rebellion and restored the dictatorial power. After being elected, President Patass announced a national unity government in early 1. The Patass government, the opposition parties, and religious groups signed the Bangui Agreements in January 1. The same year, the rebel troops refused a military base in Bangui and in June a new revolt broke out. In view of frequent political unrest the city was named in 1. On 2. 5 October 2. Bangui itself were attacked by the forces of General Franois Boziz, backed with international support. 1. Boziz refused to accept an arrest warrant and defected with about a hundred troops, engaged in street battles in the northern neighborhoods of Bangui traditionally supporting Patass and went north. Boziz went into exile in Chad but his troops returned to Bangui and fighting continued. Peace keeping forces were ineffective, leaving Patass isolated, and with support from Chad, Bozizs troops were successful in removing Patasss government. Patass, who was returning from Niger after attending a conference, was not permitted to land in Bangui and he took asylum in Togo, and Boziz seized power and suspended the constitution. An all party National Transitional Government was set up which functioned as an interim legislative body. However, the climate of distrust continued. 2. A family uses tarps taken from a refugee camp to get shelter from the sun, with bricks for rebuilding their homes all around them in the PK5 neighborhood. In late 2. 01. 2, the Slka coalition rebelled against his autocratic rule and entered the city. After capturing Bria, Sibut, and other important towns, they were on the verge of capturing Damara, the last strategic town before Bangui. France and the US refused to support the president and neighbouring countries reinforced the Central African Multinational Force Fomac. 1. In January 2. 01. 
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Our finding that CSPalpha expression is reduced in AD hippocampus and STG is consistent with another study, which was published after we started our project, showing that in Brodmann area 9 of severe Alzheimers disease CSPalpha expression is reduced by about 4. Furthermore, we also detected a downregulation of CSPalpha expression in hippocampus in mild Alzheimers disease when CSPalpha amounts were normalized to the synaptic marker synaptophysin. Vendita cuccioli di cani toy di razza, cani di tutti i tipi, cuccioli di razza con certificazione, allevamento di tutti i tipi di cani su di una vasta area dove i. Search metadata Search full text of books Search TV captions Search archived web sites Advanced Search. Design by GioVi Mitopositano com News Manciano Saturnia indexvecchia index cogn Hotels of the world Agriturismi Vacanze cardomino. Treatment of brain injury with exosomes derived from mesenchymal stromal cells MSCs enhances neurite growth. However, the direct effect of exosomes on axonal growth. 
Traditionally, synaptophysin is used as a neuropathological marker of synaptic degeneration in Alzheimers disease 3. However, our finding that CSPalpha levels are reduced without noticeable changes in synaptophysin expression, when relative neuronal expression rather than absolute protein expression is analyzed. When considering the importance of CSPalpha for synaptic function 1. CSPalpha expression is likely to be involved in the initial stages of synaptic degeneration. Further, for investigating synaptic degeneration in Alzheimers disease analysis CSPalpha expression appears more suitable than assessing synaptophysin expression. CSPalpha, along with its interacting partners Hsc 7. SGT, is involved in exocytotic mechanisms in presynaptic terminals that are mediated by its interactions with SNARE complexes 9. Downregulation of CSPalpha may therefore lead to reductions in the number of synaptic vesicles binding at presynaptic membranes, thereby affecting synaptic activity. Further, CSPalpha is also important for endocytosis of synaptic vesicles. CSPalpha interacts with dynamin to facilitate the of dynamin polymerization which is important for endocytotic vesicle fission 1. This is important for normal synaptic function since the number of synaptic vesicles readily available for exocytosis is reduced when there are defects in endocytotic fission 3. This suggests that defects observed in exocytotic mechanisms in CSPalpha knockout mice could be explained by deficits in CSPalpha dependent endocytotic mechanisms. Hence, CSPalpha downregulation could lead to loss of function at different stages of synaptic vesicular recycling to contribute to synaptic loss. Additionally, reduced CSPalpha expression is expected to increase BK channel density at synapses, which reduces excitability at presynaptic terminals 1. BK channel activation has been reported to decrease basal synaptic transmission in hippocampal CA1 region of a mouse model of Alzheimers disease 3. Loss of synaptic activity is thought to be lethal for synapses, therefore, the downregulation in CSPalpha expression we observe in Alzheimers disease hippocampus could be closely associated with synaptic degeneration and the resulting impaired memory formation in early Alzheimers disease. The second major finding from our study is the identification of CSPalpha upregulation in Alzheimers disease cerebellum. The cerebellum is relatively protected from neurodegeneration in Alzheimers disease. For example, there is no synaptic and neuronal loss in this area, although there are some diffuse amyloid plaques 1. The molecular mechanisms that impart neuroprotection to the cerebellum in Alzheimers disease are not known. Our results suggest that CSPalpha may be a factor contributing to this neuroprotection. We observed an upregulation of CSPalpha in cerebellum both in mild and severe Alzheimers disease. Importantly, we found that the level of upregulation in this region is comparable to the amounts of CSPalpha expression detected in young, healthy cerebellum, in contrast to an age dependent decrease in CSPalpha expression in normal cerebellum. Additional experimental support for the suggestion that CSPalpha upregulation could be neuroprotective in Alzheimers disease comes from our finding that CSPalpha expression is not altered in cerebellum from patients with FTLD, although there is neuropathology in the cerebellum in this disease 2. Additional support for our hypothesis comes from analysis of htau mutant mice, where we found that CSPalpha upregulation occurs only at times when no neuronal loss is observed. Taken together, the evidence we present here suggests that CSPalpha upregulation in Alzheimers disease cerebellum might be neuroprotective, although in future functional studies in model systems are needed to support this idea. How could CSPalpha upregulation protect synapses and consequently neurons in Alzheimers disease cerebellum In Alzheimers disease forebrain, amyloid induced aberrations in synaptic activity are one of the causes of synaptic toxicity 3. In particular, dysfunctional synaptic machinery could be an after effect of impaired synaptic vesicle trafficking. A oligomers impair synaptic vesicle recycling by hindering endocytosis as well as the formation of fusion competent vesicles 3. Furthermore, transgenic mouse studies have suggested that presynaptic degeneration is pivotal in Alzheimers disease 3. Considering the role of CSPalpha in endocytosis and vesicle recycling, an up regulation of CSPalpha in Alzheimers disease cerebellum could be a compensatory mechanism that prevents impairments in synaptic vesicle recycling that are induced by factors causing Alzheimers disease. This might result in protection of synapses and neurons from degeneration. Functional studies with CSPalpha knockout and upregulation models will provide further insights into the mechanistic basis of our observations. 
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